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When the Security Agent is running, the process lsass.exe's memory usage increases. The issue disappears when the Trend Micro Solution Platform service is disabled.
When you identify when the issue happened and check the Internet Information Services (IIS) logs for that period, you find the 401.1 error for port 8082 requests, like the one below:
2011-12-08 14:23:35 10.35.5.1 GET /tmcss/ LCRC=9C4E654146B6CBFA4E9DFE0CD913B3B85A0753D5E20A5BA903B68F53C506AD69 8082 - 10.35.5.66 WFBS;17.0;2316;a4f71263-504c-4cd3-b77a-f378ba2f79d5;4f337fbe-07a8-484a-9ed8-5eead0877b7f;Af9CAWBk 401 1 0
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