On October 17, 2017, Microsoft has officially released the third major update to Windows 10 operating system - more popularly known as the Windows 10 Fall Creators Update.
Trend Micro FDE agent builds 5.0 patch 4 update 1 and 6.0 support Windows 10 Fall Creators Update. This includes both fresh OS installations and OS upgrades (both in-place upgrade and through WSUS). Refer to the following KB articles: