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Below are the minimum Mail Server requirements: 
Microsoft Exchange VersionService Pack or Release
2003SP2 or above
2007SP1 or above
2010SP1, SP2 or SP3
Note: To integrate properly with the anti-spam features in Microsoft Exchange Server 2003 and 2007, the Messaging Security Agent requires the Intelligent Message Filter.
  • Exchange 2013 is supported in WFBS 9.0.
  • Messaging Security Server (MSA) supports Exchange 2010 SP3.
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