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ScanMail with Microsoft Exchange Server 2019:

Operating System
     ----------------
     - Microsoft™ Windows Server™ 2019 Standard or Datacenter(64-bit)
     - Microsoft™ Windows Server™ 2022 Standard or Datacenter(64-bit)

     Note: For ScanMail deployment on Server Core edition, Trend 
           Micro recommends running installation package on Windows 
           Server with Desktop Experience feature and deploy ScanMail 
           remotely.
     Mail Server
     -----------
     - Microsoft Exchange Server 2019
 
     Web Server
     ----------
     - Microsoft Internet Information Services (IIS) 10.0
 
     Browser
     -------
     - Mozilla Firefox™ 3.0 or above
     - Google Chrome™ 100.0 or above
     - Microsoft Edge™ 100.0 or above
 
     MSXML
     -----
     MSXML 4.0 SP2 or above
 
     .NET Framework
     --------------
     - .NET framework 4.7.2
     - .NET framework 4.8

ScanMail with Microsoft Exchange Server 2016:

Operating System
     ----------------
     - Microsoft™ Windows Server™ 2016 Standard or Datacenter(64-bit)
     - Microsoft™ Windows Server™ 2012 R2 Standard or Datacenter (64-   
       bit) 

Important
You must also install Windows Server 2012 R2 Update    
          (KB2919355 and KB2919442) with Microsoft™ Windows Server™ 
          2012 R2

     - Windows Server 2012 Standard or Datacenter
 
     Mail Server
     -----------
     - Microsoft Exchange Server 2016
 
     Web Server
     ----------
     - Microsoft Internet Information Services (IIS) 10.0
     - Microsoft Internet Information Services (IIS) 8.5
     - Microsoft Internet Information Services (IIS) 8.0
 
     Browser
     -------
     - Mozilla Firefox™ 3.0 or above
     - Google Chrome™ 100.0 or above
     - Microsoft Edge™ 100.0 or above
 
     MSXML
     -------
     MSXML 4.0 SP2 or above
 
     .NET Framework
     --------------
     - .NET Framework 4.5
     - .Net Framework 4.6.2
     - .Net Framework 4.7.1
     - .Net Framework 4.7.2 
     - .Net Framework 4.8 

The Exchange and SQL server versions mentioned in the following table are tested by Trend Micro and supported by SMEX.

Exchange 2019Exchange 2016Microsoft SQL Server
Exchange 2019 CU 3Exchange 2016 CU 4SQL Server 2012 SP4
Exchange 2019 CU 4Exchange 2016 CU 5SQL Server 2017 Express
Exchange 2019 CU 5Exchange 2016 CU 6SQL Server 2019
Exchange 2019 CU 6Exchange 2016 CU 7SQL Server 2019 Express
Exchange 2019 CU 7Exchange 2016 CU 8SQL Server 2022
Exchange 2019 CU 8Exchange 2016 CU 9SQL Server 2022 Express
Exchange 2019 CU 9Exchange 2016 CU 10 
Exchange 2019 CU 10Exchange 2016 CU 11 
Exchange 2019 CU 11Exchange 2016 CU 12 
Exchange 2019 CU 12Exchange 2016 CU 13 
Exchange 2019 CU 13Exchange 2016 CU 14 
Exchange 2019 CU 14Exchange 2016 CU 15 
 Exchange 2016 CU 16 
 Exchange 2016 CU 17 
 Exchange 2016 CU 18 
 Exchange 2016 CU 19 
 Exchange 2016 CU 20 
 Exchange 2016 CU 21 
 Exchange 2016 CU 22 
 Exchange 2016 CU 23 

The compatibility testing may not cover all the released Exchange Server and SQL Server Express updates.

You may also refer to the Microsoft Lifecycle Policy page for further information.

Contact Trend Micro Technical Support to confirm the support status before implementing any new Exchange Servers that are not listed here.

See the detailed system requirements in the following readme file: