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To resolve the issue:

Refer customer to the following Microsoft KB Article: Recommended antivirus exclusions for Hyper-V hosts.

If scan exclusions are already set, but the issue persists, request OfficeScan 11.0 Hot Fix Build 6447 from Trend Micro Technical Support or apply the latest patch from Trend Micro Download Center.

Once the hot fix has been applied:

  1. Open the Ofcscan.ini file in the \PCCSRV\ folder on the OfficeScan server installation directory using a text editor.
  2. Under the Global Setting section, manually add the following key and set its value to "1".

    [Global Setting]
    SP_DisableTmLwfRegistryKeyProtection=1

  3. Save the change and close the file.
  4. Open the OfficeScan web console and go to the Agents > Global Agent Settings screen.
  5. Click Saveto deploy the setting to agents.

    The OfficeScan server deploys the command to OfficeScan agents and adds the following registry entry on all OfficeScan agent computers:

    Path: HKEY_LOCAL_MACHINE\SOFTWARE\Wow6432Node\TrendMicro\PC-cillinNTCorp\CurrentVersion\AEGIS
    Key: SP_DisableTmLwfRegistryKeyProtection
    Type: DWORD
    Value: 1

Verify if the issue persists.