You are unable to perform remote query after verifying the following on both local and remote servers:

• RPC and SMEX Remote Config service are started.
• HKLM\SOFTWARE\TrendMicro\ScanMail for Exchange\CurrentVersion\EnableTLSQuery (DWORD) = 1
• Both servers are using the same Activation Code (AC) and running in the same version.

In the debug log, it can be seen that SMEX attempts to connect to the remote server on port 16373, while it is using HTTPS on port 16372:

2018/05/29 13:34:07 +0200 [22336:17436] [ utilremotetask.dll][ util_remotetask.cpp(2818)] [DEBUG] CURL_DBG(): connect to 172.25.23.1 port 16373 failed: Timed out   2018/05/29 13:34:07 +0200 [22336:17436] [ utilremotetask.dll][ util_remotetask.cpp(2818)] [DEBUG] CURL_DBG(): Failed to connect to .nsgbeg.local port 16373: Timed out   2018/05/29 13:34:07 +0200 [22336:17436] [ utilremotetask.dll][ util_remotetask.cpp(2818)] [DEBUG] CURL_DBG(): Closing connection 0   2018/05/29 13:34:07 +0200 [22336:17436] [ utilremotetask.dll][ util_remotetask.cpp(3007)] [ERROR] task_thread(): Failed at login. Err(7)   2018/05/29 13:34:07 +0200 [22336:17436] [ utilremotetask.dll][ util_remotetask.cpp(3008)] [ERROR] task_thread(): Err Msg: Failed to connect to .nsgbeg.local port 16373: Timed out   2018/05/29 13:34:07 +0200 [22336:17436] [ utilremotetask.dll][ util_remotetask.cpp(2464)] [DEBUG] task_thread(): Total elapsed time(21528)