To resolve the issue:

1. Open the Ofcscan.ini file in the \PCCSRV\ folder on the OfficeScan server installation directory using a text editor.
2. Under the Global Setting section, manually add the following key and set its value to "1":

   SP_DisableTmLwfRegistryKeyProtection=1

   It will look like this:

   [Global Setting]
   SP_DisableTmLwfRegistryKeyProtection=1

3. Save the changes and close the file.
4. Open the OfficeScan web console and go to the Agents > Global Agent Settings screen.
5. Click Save to deploy the setting to agents.

To check if the settings have been applied, perform a manual update on the target endpoint.

The OfficeScan server deploys the command to OfficeScan agents and adds the following registry entry on OfficeScan agent computers:

Path: HKEY_LOCAL_MACHINE\SOFTWARE\Wow6432Node\TrendMicro\PC-cillinNTCorp\CurrentVersion\AEGIS
Key: SP_DisableTmLwfRegistryKeyProtection
Type: DWORD
Value: 1

If the registry above is in place, then issue should be resolved.