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First and foremost, Trend Micro does not suggest, nor officially support, the installation of both Apex One full feature agent with Malwarebytes endpoint anti-virus products as stated in this article.

As Apex One covers all of the functionality of the Malwarebytes endpoint products, it makes this setup redundant while introducing the possibility of issues when operating simultaneously together.

Feature Comparison of Apex One and Malwarebytes

FeaturesApex OneMalwareBytes
ENDPOINT SECURITY
Anti-Malware✔️✔️
Machine LearningPre-Execution, RuntimePre-Execution
Malware Behavior Blocking✔️✔️
Ransomware Protection✔️✔️
Web Threat Protection✔️✔️
Anti-Exploit✔️✔️
Virtual Patching✔️
Application Whitelisting✔️
Sandbox AnalysisCloud/On-PremCloud
ENDPOINT DETECTION AND RESPONSE
Continuous Endpoint Activity Recording✔️✔️
Endpoint & Email Correlation
(XDR for Users)
✔️
Root Cause Analysis✔️✔️
Historical/Live Investigations✔️
Automated Response✔️✔️
Endpoint Isolation✔️✔️
Advanced RemediationIn Roadmap✔️
DATA PROTECTION
Data Loss Prevention (DLP)✔️
Device Control✔️
PLATFORM SUPPORT
Single Agent✔️✔️
SaaS/On-Prem DeploymentSaaS, On-PremSaaS
Supported PlatformsWindows, Mac, LinuxWindows, Mac

If the need to install both products on the same host is required, then the application of mutual exclusions to both products is necessary.