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On the SQL Server the User account used to access the SQL database may have lost their permissions to the database. Recheck the account permissions and if the issue persists please open a new case with Trend Micro support and provide CDT debug logs for analysis as per instructions below. Please ensure that while capturing the debug logs the Scanmail Master service is restarted.

https://success.trendmicro.com/solution/KA-0003253