As described here , adding a sender or sending domain to the Approved Sender list will ensure the mail bypasses the following checks:
- IP reputation-based filtering
- Unknown sender domain check
- Spam
- BEC
- Phishing
- Social engineering attack
- Web reputation
- Graymail
Trend Micro Email Security still performs virus scanning and content filtering on all messages received and takes the action configured in policy rules once detecting any virus or content filtering violation.