To resolve this issue, assign an IP address on the OfficeScan client to use when sending data to the OfficeScan server.
Add the "IP Template" parameter on the client with multiple NICs or on the SQL cluster that uses the 169.254 segment for cluster traffic.

1. On the security server, go to the ..\PCCSRV folder and open the ofcscan.ini file using text editor.
2. Under the [Global Setting] section, add the following key and assign the valid IP address for the OfficeScan server:

   IPTemplateDeployEnable=1
   IPTemplateDeploy=<assign_a_valid_IP_address_range_used_to_connect_to_the_officescan_server>

   For example:

   [Global Setting]
   IPTemplateDeployEnable=1
   IPTemplateDeploy0=10.200.10.x

    

   If some of your clients have 2 or more network cards, set the range to the ones you will be using to connect.

   IPTemplateDeploy1=10.210.x.x

    

   Same for a different range on a different client.

   IPTemplateDeploy2=10.211.10.X
   IPTemplateDeploy3=10.211.30.X
   IPTemplateDeploy4=172.18.x.x
   IPTemplateDeploy5=172.17.x.x
   IPTemplateDeploy6=172.16.x.x
   IPTemplateDeploy7=192.168.50.X
   IPTemplateDeploy8=192.168.30.X
   IPTemplateDeploy9=192.168.10.X

    

   Only the characters x and X can be used. The wildcard * is not supported. This will deploy the settings on the officescan.ini file to clients within the range defined by those symbols.
3. Save and close the file.
4. Log on to the OfficeScan server management console.
5. Deploy Global Settings:
   • In OfficeScan 10.x, go to Networked Computers > Global Client Settings and click Save to deploy the settings to the clients.
   • In OfficeScan 11.0/XG, go to Agents > Global Agent Settings and click Save to deploy the settings to the clients.

   The OfficeScan client program automatically installs the following registry keys:

   Key: HKLM\SOFTWARE\TrendMicro\PC-cillinNTCorp\CurrentVersion
   Name: IPTemplateDeployEnable
   Type: REG_DWORD
   Data: 1

   Key: HKLM\SOFTWARE\TrendMicro\PC-cillinNTCorp\CurrentVersion
   Name: IPTemplateDeploy0 to IPTemplateDeploy9
   Type: REG_SZ
   Data: the assigned IP address

In OfficeScan 10.0 Service Pack 1 and above, you will not be able to directly edit the registry if self-protection is enabled. This setting should be deployed using the IPTemplateDeploy method from the ofcscan.ini global settings.