This article answers whether OfficeScan supports Windows 8/10 To Go or not.
Windows To Go is a feature in Windows 8.1 Enterprise, Windows 8 Enterprise, Windows 10 Enterprise, and Windows 10 Education that allows them to boot and run from certain USB mass storage devices such as USB flash drives and external hard disk drives which have been certified by Microsoft as compatible.
OfficeScan 10.6, 11.0, and XG do not support Windows To Go because this Windows 8/10 feature was not included during product testing. There is no roadmap yet that indicates if this feature will be included in future OSCE releases.