Yes, OfficeScan 10.5, 10.6, and 11.0 support VMware ESX 3.5 and 4.x (Server Edition). In addition, OfficeScan supports the following virtualization solutions:
- VMware Server 2 (Server Edition)
- VMware Workstation and Workstation ACE Edition 7.0
- VMware vCenter™ 4
- Citrix™ XenServer™ 5.5 and 5.6
- Microsoft Windows Server 2008 64-bit Hyper-V™
- Microsoft Windows Server 2008 R2 64-bit Hyper-V
- Microsoft Hyper-V Server 2008 R2 64-bit
For the latest supported system requirements, visit the OfficeScan documentation page.