Yes, OfficeScan 10.5, 10.6, and 11.0 support VMware ESX 3.5 and 4.x (Server Edition). In addition, OfficeScan supports the following virtualization solutions:

• VMware Server 2 (Server Edition)
• VMware Workstation and Workstation ACE Edition 7.0
• VMware vCenter™ 4
• Citrix™ XenServer™ 5.5 and 5.6
• Microsoft Windows Server 2008 64-bit Hyper-V™
• Microsoft Windows Server 2008 R2 64-bit Hyper-V
• Microsoft Hyper-V Server 2008 R2 64-bit

For the latest supported system requirements, visit the OfficeScan documentation page.