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To resolve the issue:

 
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  1. Open IIS Manager and double-click the local computer icon.
  2. Right-click Application Pools and then click New > Application Pool.
  3. Choose one of these options:
    • Use default settings for new application pool (recommended)
    • Use existing application pool as template - This option will require you to choose an Application Pool name.
  4. Click OK.
  5. Return to the local computer icon and find the new Application Pool.
  6. Right-click the Application Pool and click Properties.
  7. Click the Identity tab and choose one of these options:
    • Predefined (recommended)
      • This refers to the standard service accounts like Network Service (default), Local Service, and Local System.
         
        You can reduce security vulnerability by using a very low-privileged account such as Network Service.
      • This requires you to choose a predefined account from the option list.
    • Configurable
      • This refers to registered user names.
      • This option requires you to specify the username and password of the account under which the worker process will operate.
  8. Click OK.
  9. Look for the OfficeScan virtual web site.
  10. Right-click the virtual web site and click Properties.
  11. Click the Home Directory tab and select the created Application Pool.
  12. Click OK when the Inheritance Overrides prompt shows up.
  13. Stop and restart the OfficeScan virtual web site.