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Cloud App Security (TMCAS) submits suspicious files (including email attachments and uploaded files) and URLs (included in files and email message bodies) to a hosted Virtual Analyzer. Virtual Analyzer is an isolated virtual environment used to manage and analyze samples in the cloud. 

Virtual Analyzer is a cloud sandbox designed for analyzing suspicious files. Sandbox images allow observation of file behavior in an environment that simulates endpoints on your network without any risk of compromising the network.

Virtual Analyzer works in conjunction with Threat Connect, the Trend Micro global intelligence network that provides actionable information and recommendations for dealing with threats.

TMCAS sends suspicious files to Virtual Analyzer when a file exhibits suspicious characteristics and signature-based scanning technologies cannot find a known threat. Virtual Analyzer performs static analysis and behavior simulation in various runtime environments to identify potentially malicious characteristics. During analysis, Virtual Analyzer rates the characteristics in context and then assigns a risk level to the sample based on the accumulated ratings.

 
A suspicious object is a known malicious or potentially malicious IP address, domain, URL, or SHA-1 value found in submitted samples. Trend Micro Threat Connect correlates suspicious objects detected in your environment and threat data from the Trend Micro Smart Protection Network to provide relevant and actionable intelligence.
 

Here are the performance of suspicious object analysis for your reference:

  • Average scanning file in sandbox: 200 seconds
  • Average scanning url in sandbox: 100 seconds

In addition, the communication between Azure DC and Trend Micro DC (hosted sandbox) is using protocol TLS v1.2, and cipher is AES256-SHA.