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To create an MDM profile for macOS Big Sur and Airwatch / JAMF:

Open the JAMF or Airwatch MDM Server, go to Device > Profiles, and click Add to add a new macOS Profile.

 
It is important to specify which OS the profile is for to prevent format issues.
 

Open the MDM console to access the device profile page

  1. Go to Security and Privacy.
  2. Under Gatekeeper, select Anywhere or Allow apps outside Mac App store

o to Security and Privacy and have the Gatekeeper to select “Anywhere” or allow apps outside Mac App store

 
For more information about macOS' Gatekeeper, read this article from Apple: Using Gatekeeper in macOS deployments.
 
  1. Go to Kernel Extension Policy, and tick the Allow User Overrides option.
  2. Indicate the Allowed Kernel Extensions for Apex Mac Service:
    • identifier "com.trendmicro.icore" and anchor apple generic and certificate 1[field.1.2.840.113635.100.6.2.6] /* exists */ and certificate leaf[field.1.2.840.113635.100.6.1.13] /* exists */ and certificate leaf[subject.OU] = E8P47U2H32    
    • identifier "com.trendmicro.tmsm.MainUI" and anchor apple generic and certificate 1[field.1.2.840.113635.100.6.2.6] /* exists */ and certificate leaf[field.1.2.840.113635.100.6.1.13] /* exists */ and certificate leaf[subject.OU] = E8P47U2H32
    •  identifier "com.trendmicro.icore.es" and anchor apple generic and certificate 1[field.1.2.840.113635.100.6.2.6] /* exists */ and certificate leaf[field.1.2.840.113635.100.6.1.13] /* exists */ and certificate leaf[subject.OU] = E8P47U2H32

o to Security and Privacy and have the Gatekeeper to select “Anywhere” or allow apps outside Mac App store

Apple Identifier in exact keywords: 

  1. Go to Privacy Preferences.
  2. Navigate to the Apple Identifier section, and add the following value to the "Receiver Code Requirement" field:
    Identifier "com.apple.systemevents" and anchor apple

Apply the Apple Identifier

 
After deploying the MDM profile to the Mac machines, configure the browser plugin information and MDM configuration for older versions of macOS. Check the following article for reference: Information needed when configuring MDM Profile for Apex One (Mac).