Customers who have upgraded to Standard Endpoint Protection may notice that the 'Scan Now' functionality is disabled in the Apex One console. This is by product design, and the scan must be conducted from Trend Vision One instead.
Please refer to the 'Scan for Malware Task' document on Trend Micro Service Central for more information on how to conduct a scan using Trend Vision One.
https://docs.trendmicro.com/en-us/documentation/article/trend-vision-one-scan-for-malware